Biohumoral Tests in Chronic Pesticides Exposure
نویسندگان
چکیده
Pesticides are an important hazard in agriculture. They are used throughout the world and their use is strictly regulated. To assess the effects of exposure to complex mixtures of pesticides, enzyme activities are among the biomarkers that may be used to detect these effects before adverse clinical health effects occur. Exposure to pesticides for a prolonged period affects the normal functioning of different organ systems, such as the liver. Chronic liver fibrosis is the most frequent consequence of pesticides exposure. Various markers are commonly used to facilitate diagnosis and to evaluate treatment efficacy. Significant increase is found for transaminases, LDH, CK, reflecting cytotoxicity. The serological tests of liver fibrosis include the main extracellular-matrix (ECM) constituents, which are broken down by a family of enzymes known as matrix metalloproteinases (MMPs). They are useful to assess the speed of liver fibrogenesis.
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تاریخ انتشار 2012